Substituted benzocoumarin derivatives: synthesis, characterization, biological activities and molecular docking with ADME studies

Herein, an efficient and convenient method for the synthesis of 4-(substitutedphenyl)-1,2-dihydro-2-oxo-6-(2-oxo-2H-benzo[g]chromen-3-yl)pyridine-3-carbonitrile derivatives have been reported using ammonium acetate as catalyst. The structures synthesized compounds were confirmed FT-IR, 1H, 13C-NMR LC-MS spectroscopic techniques. evaluated antibacterial activity against bacterial strains by agar diffusion at different concentrations. Further, all targeted screened anti-oxidant anti-cancer studies DPPH MTT assay methods Compound 4b displayed good antioxidant anticancer (against MCF-7 cell line) activity. binding capability (4a–j) was analyzed molecular docking human peroxiredoxin 5 (PDB ID: 1HD2) P38 MAP kinase 1OUK) protein. physicochemical properties analysed from ADME respectively.